Islet Transplantation in Diabetes: the Pittsburgh Experience
نویسندگان
چکیده
Nineteen-ninety was a significant year for clinical islet transplantation, since after many attempts reports of short terml and prolonged2.6 insulin independence following human islet allotransplantation, indicated that it is possible to replace the endocrine function of the pancreas by an islet transplant in man. The development of improved procedures for islet isolation and purification from large animals7. 11 and humanl2.16 pancreata have resulted in significant progress in both the number and purity of islets that can be obtained from each pancreas. In addition, the use of more powerful immunosuppressive agents such as cyclosporine A 1.3.16 or FK5062,6 resulted in prolonged human islet allograft survival in some cases. This report summarized our initial experience on islet isolation and intrahepatic allotransplantation.
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